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Graphical contents list • MISCELLANEOUS PDF (622 K) | |||
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In vitro monitoring of nanogram levels of puerarin in human urine using flow injection chemiluminescence • SHORT COMMUNICATION Changna Wang and Zhenghua Song SummaryPlus | Full Text + Links | PDF (251 K) | |||
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Design and synthesis of cyclic urea compounds: a pharmacological study for retinoidal activity • SHORT COMMUNICATION Masaaki Kurihara, Abu Shara Shamsur Rouf, Hisao Kansui, Hiroyuki Kagechika, Haruhiro Okuda and Naoki Miyata SummaryPlus | Full Text + Links | PDF (380 K) | |||
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Synthesis and biological evaluation of novel 4″-alkoxy avermectin derivatives • SHORT COMMUNICATION Kenichiro Nagai, Kazuro Shiomi, Toshiaki Sunazuka, Achim Harder, Andreas Turberg and Satoshi SummaryPlus | Full Text + Links | PDF (289 K) | |||
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Phenylhomophthalimide-type NOS inhibitors derived from thalidomide • SHORT COMMUNICATION Tomomi Noguchi, Hiroko Sano, Rumiko Shimazawa, Aya Tanatani, Hiroyuki Miyachi and Yuichi Hashimoto SummaryPlus | Full Text + Links | PDF (285 K) | |||
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Benzodiazepine inhibitors of the MMPs and TACE. Part 2 • SHORT COMMUNICATION Jeremy I. Levin, Frances C. Nelson, Efren Delos Santos, Mila T. Du, Gloria MacEwan, James M. Chen, Semiramis Ayral-Kaloustian, Jun Xu, Guixian Jin, Terri Cummons and Dauphine Barone SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Rapid cleavage of cyclic tertiary amides of Kemp's triacid: effects of ring structure • SHORT COMMUNICATION Michael L. Dougan, Jonathan L. Chin, Ken Solt and David E. Hansen SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Thiourea inhibitors of herpesviruses. Part 3: Inhibitors of varicella zoster virus • SHORT COMMUNICATION Martin J. Di Grandi, Kevin J. Curran, Gregg Feigelson, Amar Prashad, Adma A. Ross, Robert Visalli, Jeanette Fairhurst, Boris Feld and Jonathan D. Bloom SummaryPlus | Full Text + Links | PDF (253 K) | |||
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Low molecular weight thrombin inhibitors with excellent potency, metabolic stability, and oral bioavailability • SHORT COMMUNICATION Matthew M. Morrissette, Kenneth J. Stauffer, Peter D. Williams, Terry A. Lyle, Joseph P. Vacca, Julie A. Krueger, S. Dale Lewis, Bobby J. Lucas, Bradley K. Wong, Rebecca B. White et al. SummaryPlus | Full Text + Links | PDF (282 K) | |||
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Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors • SHORT COMMUNICATION Arthur Gomtsyan, Stanley Didomenico, Chih-Hung Lee, Andrew O. Stewart, Shripad S. Bhagwat, Elizabeth A. Kowaluk and Michael F. Jarvis Abstract | PDF (262 K) | |||
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Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators • SHORT COMMUNICATION J. T. Link, Bryan K. Sorensen, Jyoti Patel, David Arendsen, Gaoquan Li, Susan Swanson, Bach Nguyen, Maurice Emery, Marlena Grynfarb and Annika Goos-Nilsson Abstract | PDF (268 K) | |||
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Synthesis, activity, metabolic stability, and pharmacokinetics of glucocorticoid receptor modulator–statin hybrids • SHORT COMMUNICATION J. T. Link, Bryan K. Sorensen, Chunqiu Lai, Jiahong Wang, Steven Fung, Daisy Deng, Maurice Emery, Sherry Carroll, Marlena Grynfarb, Annika Goos-Nilsson and Thomas von Geldern Abstract | PDF (301 K) | |||
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Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator • SHORT COMMUNICATION Noah Tu, J. T. Link, Bryan K. Sorensen, Maurice Emery, Marlena Grynfarb, Annika Goos-Nilsson and Bach Nguyen Abstract | PDF (295 K) | |||
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Synthesis and QSAR studies of pyrimido[4,5-d]pyrimidine-2,5-dione derivatives as potential antimicrobial agents • SHORT COMMUNICATION Pratibha Sharma, Nilesh Rane and V. K. Gurram SummaryPlus | Full Text + Links | PDF (293 K) | |||
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Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents • SHORT COMMUNICATION Marc Nazaré, Melanie Essrich, David W. Will, Hans Matter, Kurt Ritter, Matthias Urmann, Armin Bauer, Herman Schreuder, Angela Dudda, Jörg Czech et al. Abstract | PDF (271 K) | |||
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Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand • SHORT COMMUNICATION Marc Nazaré, Melanie Essrich, David W. Will, Hans Matter, Kurt Ritter, Matthias Urmann, Armin Bauer, Herman Schreuder, Jörg Czech, Martin Lorenz et al. Abstract | PDF (264 K) | |||
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Copper dipicolinates as peptidomimetic ligands for the Src SH2 domain • SHORT COMMUNICATION Boris Schmidt, Jan Jiricek, Alexander Titz, Guofeng Ye and Keykavous Parang SummaryPlus | Full Text + Links | PDF (271 K) | |||
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Amino porphyrins as photoinhibitors of Gram-positive and -negative bacteria • SHORT COMMUNICATION V. Sol, P. Branland, V. Chaleix, R. Granet, M. Guilloton, F. Lamarche, B. Verneuil and P. Krausz SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Synthesis of 7 - and 7 -spermidinylcholesterol, squalamine analogues • SHORT COMMUNICATIONB. Choucair, M. Dherbomez, C. Roussakis and L. El kihel SummaryPlus | Full Text + Links | PDF (262 K) | |||
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Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data • SHORT COMMUNICATION Qian Wu, Kevin R. Criscione, Gary L. Grunewald and Michael J. McLeish SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Identification of [(naphthalene-1-carbonyl)-amino]-acetic acid derivatives as nonnucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase • SHORT COMMUNICATION Ariamala Gopalsamy, Kitae Lim, John W. Ellingboe, Girija Krishnamurthy, Mark Orlowski, Boris Feld, Marja van Zeijl and Anita Y. M. Howe SummaryPlus | Full Text + Links | PDF (267 K) | |||
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Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX2R) antagonists • SHORT COMMUNICATION Laura C. McAtee, Steven W. Sutton, Dale A. Rudolph, Xiaobing Li, Leah E. Aluisio, Victor K. Phuong, Curt A. Dvorak, Timothy W. Lovenberg, Nicholas I. Carruthers and Todd K. Jones Abstract | PDF (260 K) | |||
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Bis-quinolinium cyclophanes: toward a pharmacophore model for the blockade of apamin-sensitive SKCa channels in sympathetic neurons • SHORT COMMUNICATION Dimitrios Galanakis, C. Robin Ganellin, Jian-Quing Chen, Diyan Gunasekera and Philip M. Dunn SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Synthesis and biological activity of 2-anilino-4-(1H-pyrrol-3-yl) pyrimidine CDK inhibitors • SHORT COMMUNICATION Shudong Wang, Gavin Wood, Christopher Meades, Gary Griffiths, Carol Midgley, Iain McNae, Campbell McInnes, Sian Anderson, Wayne Jackson, Mokdad Mezna et al. SummaryPlus | Full Text + Links | PDF (349 K) | |||
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Rational drug design and synthesis of a selective  opioid receptor antagonist on the basis of the accessory site concept • SHORT COMMUNICATIONHideaki Fujii, Minoru Narita, Hirokazu Mizoguchi, Junichi Hirokawa, Koji Kawai, Toshiaki Tanaka, Leon F. Tseng and Hiroshi Nagase SummaryPlus | Full Text + Links | PDF (268 K) | |||
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Aminotriazine 5-HT7 antagonists • SHORT COMMUNICATION Ronald J. Mattson, Derek J. Denhart, John D. Catt, Michael F. Dee, Jeffrey A. Deskus, Jonathan L. Ditta, James Epperson, H. Dalton King, Aiming Gao, Michael A. Poss et al. SummaryPlus | Full Text + Links | PDF (273 K) | |||
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Diaminopyrimidine and diaminopyridine 5-HT7 ligands • SHORT COMMUNICATION Derek J. Denhart, Ashok V. Purandare, John D. Catt, H. Dalton King, Aiming Gao, Jeffrey A. Deskus, Michael A. Poss, Arlene D. Stark, John R. Torrente, Graham Johnson and Ronald J. Mattson SummaryPlus | Full Text + Links | PDF (250 K) | |||
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Novel (3,5-di-tert-butyl-2-hydroxy-phenylcarbamoyl)-alkanoic acids as potent antioxidants • SHORT COMMUNICATION Vladimir I. Lodyato, Irina L. Yurkova, Viktor L. Sorokin, Oleg I. Shadyro, Vladimir I. Dolgopalets and Mikhail A. Kisel SummaryPlus | Full Text + Links | PDF (311 K) | |||
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Structure–activity relationships of methylene or terminal side chain modified retinoids on the differentiation and cell death signaling in NB4 promyelocytic leukemia cells • SHORT COMMUNICATION Diana Ivanova, Aurélie Rossin, Hinrich Gronemeyer, Alain Valla, Dominique Cartier, Régis Le Guillou and Roger Labia SummaryPlus | Full Text + Links | PDF (324 K) | |||
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Pharmacological evaluation of selected arylpiperazines with atypical antipsychotic potential • SHORT COMMUNICATION Mirko Tomi Abstract | PDF (263 K) | |||
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The development of novel inhibitors of tumor necrosis factor- (TNF-) production based on substituted [5,5]-bicyclic pyrazolones • SHORT COMMUNICATION Matthew J. Laufersweiler, Todd A. Brugel, Michael P. Clark, Adam Golebiowski, Roger G. Bookland, Steven K. Laughlin, Mark P. Sabat, Jennifer A. Townes, John C. VanRens, Biswanath De et al. Abstract | PDF (313 K) | |||
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The -glucuronyl-based prodrug strategy allows for its application on -glucuronyl-platinum conjugates • SHORT COMMUNICATION Reynier A. Tromp, Stella S. G. E. van Boom, C. Marco Timmers, Steven van Zutphen, Gijsbert A. van der Marel, Herman S. Overkleeft, Jacques H. van Boom and Jan Reedijk SummaryPlus | Full Text + Links | PDF (320 K) | |||
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Acyl-CoA: cholesterol acyltransferase inhibitory activities of fatty acid amides isolated from Mylabris phalerate Pallas • SHORT COMMUNICATION Ming-Zhe Xu, Woo Song Lee, Mi Jeong Kim, Doo-Sang Park, Hana Yu, Guan-Rong Tian, Tae-Sook Jeong and Ho-Yong Park SummaryPlus | Full Text + Links | PDF (253 K) | |||
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Structure–activity relationships of potent and selective factor Xa inhibitors: benzimidazole derivatives with the side chain oriented to the prime site of factor Xa • SHORT COMMUNICATION Hiroshi Ueno, Susumu Katoh, Katsuyuki Yokota, Jun-ichi Hoshi, Mikio Hayashi, Itsuo Uchida, Kazuo Aisaka, Yasunori Hase and Hidetsura Cho Abstract | PDF (324 K) | |||
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Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter • SHORT COMMUNICATION Makoto Kimura, Tomoko Masuda, Koji Yamada, Nobuyuki Kawakatsu, Nobuo Kubota, Masaki Mitani, Kenichi Kishii, Masato Inazu, Yuji Kiuchi, Katsuji Oguchi and Takayuki Namiki SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Rational design of potent and selective NH-linked aryl/heteroaryl cathepsin K inhibitors • SHORT COMMUNICATION Joël Robichaud, Christopher Bayly, Renata Oballa, Peppi Prasit, Christophe Mellon, Jean-Pierre Falgueyret, M. David Percival, Gregg Wesolowski and Sevgi B. Rodan Abstract | PDF (356 K) | |||
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A unidirectional crosslinking strategy for HIV-1 protease dimerization inhibitors • SHORT COMMUNICATION You Seok Hwang and Jean Chmielewski SummaryPlus | Full Text + Links | PDF (474 K) | |||
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,-Difluoro--ketophosphonates as potent inhibitors of protein tyrosine phosphatase 1B • SHORT COMMUNICATION Xianfeng Li, Ashok Bhandari, Christopher P. Holmes and Anna K. Szardenings Abstract | PDF (275 K) | |||
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Synthesis and structure–activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists • SHORT COMMUNICATION Michele A. Weidner-Wells, Todd C. Henninger, Stephanie A. Fraga-Spano, Christine M. Boggs, Michele Matheis, David M. Ritchie, Dennis C. Argentieri, Michael P. Wachter and Dennis J. Hlasta Abstract | PDF (272 K) | |||
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Molecular mechanisms of adefovir sensitivity and resistance in HBV polymerase mutants: a molecular dynamics study • SHORT COMMUNICATION Vikas Yadav and Chung K. Chu SummaryPlus | Full Text + Links | PDF (575 K) | |||
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Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine • SHORT COMMUNICATION Vasudha Sharma and Jetze J. Tepe SummaryPlus | Full Text + Links | PDF (245 K) | |||
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Monoclonal antibody mediated intracellular targeting of tallysomycin S10b • SHORT COMMUNICATION Michael A. Walker, H. Dalton King, Richard A. Dalterio, Pamela Trail, Raymond Firestone and Gene M. Dubowchik SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Tubulin inhibitors. Synthesis and biological activity of HTI-286 analogs with B-segment heterosubstituents • SHORT COMMUNICATION Chuan Niu, Daniel Smith, Arie Zask, Frank Loganzo, Carolyn Discafani, Carl Beyer, Lee Greenberger and Semiramis Ayral-Kaloustian SummaryPlus | Full Text + Links | PDF (302 K) | |||
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P4 cap modified tetrapeptidyl -ketoamides as potent HCV NS3 protease inhibitors • SHORT COMMUNICATION David X. Sun, Lifei Liu, Beverly Heinz, Alexander Kolykhalov, Jason Lamar, Robert B. Johnson, Q. May Wang, Yvonne Yip and Shu-Hui Chen SummaryPlus | Full Text + Links | PDF (294 K) | |||
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Design and synthesis of novel Cdc25A-inhibitors having phosphate group as a hydrophilic residue • SHORT COMMUNICATION Rumiko Shimazawa, Mika Gochomori and Ryuichi Shirai SummaryPlus | Full Text + Links | PDF (262 K) | |||
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Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display • SHORT COMMUNICATION Takayuki Yamazaki, Satoko Aoki, Keisuke Ohta, Shinji Hyuma, Kengo Sakaguchi and Fumio Sugawara SummaryPlus | Full Text + Links | PDF (284 K) | |||
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Synthesis, biophysical and biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as potent G-quadruplex-binding telomerase inhibitors • SHORT COMMUNICATION Christoph M. Schultes, Bérangère Guyen, Javier Cuesta and Stephen Neidle SummaryPlus | Full Text + Links | PDF (321 K) | |||
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D-piece modifications of the hemiasterlin analog HTI-286 produce potent tubulin inhibitors • SHORT COMMUNICATION Arie Zask, Gary Birnberg, Katherine Cheung, Joshua Kaplan, Chuan Niu, Emily Norton, Ayako Yamashita, Carl Beyer, Girija Krishnamurthy, Lee M. Greenberger et al. Abstract | PDF (288 K) | |||
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Editorial board • MISCELLANEOUS PDF (219 K) | |||
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Contributors to this issue • MISCELLANEOUS PDF (190 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (70 K) | |||
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